There's a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to minimize afferent soreness transmission and deliver analgesia. As a result, drugs like clonidine that target alpha-2 receptors can impact the transmission of ache. You may be able to https://www.proleviate.com/post/the-new-pain-killer-conolidine